个人信息：

姓名：成楚

性别：女

职称：讲师

毕业院校：东南大学

专业：生物医学工程

研究方向：疾病早期诊断、靶向药系统构建、生物信息技术

邮箱：chengchu@whpu.edu.cn

科研项目：

1． 安徽省重点研究与开发计划，2023i11020009。生物标记物—系列荧光标记修饰核苷酸产品研发与产业化，2023-08-01至2025-12-31，在研，参与；

2． 国家自然科学基金面上项目，61971123。新型两核苷酸合成测序技术及其应用研究, 2020- 01-01 至 2023-12-31, 结题, 参与；

3． 国家自然科学基金面上项目,31970817。细胞极性蛋白Miranda通过控制Prospero的阈值性分布精确调控肠道干细胞数目的分子机制研究, 2020-01-01 至 2023-12-31，结题, 参与；

4． 国家农业部“948”项目，2014-Z27。产丁酸菌及发酵工艺关键技术引进与消化，2014-01至2015-12，结题，参与。

论文成果：

1. Chu Cheng and Pengfeng Xiao*. Evaluation of the correctable decoding sequencing as a new powerful strategy for DNA sequencing. Life Science Alliance, 2022, 5: e202101294.

2. Chu Cheng, Zhongjie Fei, Pengfeng Xiao*, Huan Huang*, Guohua Zhou*, and Zuhong Lu. Analysis for mutational genotyping using correctable decoding sequencing with superior specificity. Analyst, 2023, 148 (2): 402-411.

3. Chu Cheng, Zhongjie Fei, and Pengfeng Xiao*. Methods to improve the accuracy of next-generation sequencing. Frontiers in Bioengineering and Biotechnology, 2023, 11: 982111.

4. Chu Cheng, Xingyue Gu, Zhongjie Fei, and Pengfeng Xiao*. An Algorithm-optimized Scheme for In-situ Synthesis of DNA Microarrays. Combinatorial Chemistry & High Throughput Screening, 2023, 26: 1609-1617.

5. Chu Cheng*, Qingzhou Cheng, Wei Zhou, Yulong Chen, Pengfeng Xiao. Highly accurate single-color fluorogenic DNA decoding sequencing for mutational genotyping. Journal of Pharmaceutical and Biomedical Analysis, under review.

6. Chu Cheng*, Qingzhou Cheng, Wei Zhou, Yulong Chen, Zhiling Zhang, Jingsi Ye, Pengfeng Xiao. A correctable decoding sequencing enables high accuracy with high throughput. Analytical methods, under review.

7. Zhongjie Fei, Chu Cheng, Rongbin Wei, Guolei Tan, and Pengfeng Xiao*. Reversible superhydrophobicity unyielding magnetic beads of flipping-triggered (SYMBOL) regulate the binding and unbinding of nucleic acids for ultra-sensitive detection. Chemical Engineering Journal, 2022, 431: 133953.

8. Zhiping Xiao，Chu Cheng, Teng Bao, Lujie Liu, Bin Wang, Wenjing Tao, Xun Pei, Shang-Tian Yang, Minqi Wang*. Production of butyric acid from acid hydrolysate of corn husk in fermentation by Clostridium tyrobutyricum: Kinetics and process economic analysis. Biotechnology for Biofuels, 2018, 11: 164-177.

9. Zhongjie Fei, Ping Liu, Chu Cheng, Rongbin Wei, Pengfeng Xiao* and Youfa Zhang*. Solvent-Responsive Magnetic Beads for Accurate Detection of SARS-CoV-2. ACS applied materials & interfaces, 2023, 15 (4): 4924-4934.

专利成果：

1.肖鹏峰; 成楚. 一种3'端羟基可逆封闭核苷酸合成测序法.中国发明专利：ZL202011152063.0；

2.成楚，肖鹏峰. 一种基于核苷酸二聚体为单体的合成测序方法.中国发明专利：CN202211002982.9；

3.成楚，肖鹏峰，章志凌，叶静斯. 一种基于标记两类不同核苷酸合成测序方法.中国发明专利：202410615860X；

4.董帅，成楚，肖鹏峰.一种基于通用碱基的核酸适配体筛选方法.中国发明专利：2024107780332；

5.成楚，赵祥伟，肖鹏峰.DNA微阵列合成优化软件.软件著作权：2023SR0467062。

学术交流：

美国俄亥俄州立大学访问学者。