基本信息

姓名：程雅红

毕业院校：武汉大学药学院

专业：神经药理学

学历：博士

研究方向

1. 情绪和食品添加剂介导的糖脂代谢变化对脑神经生理病理影响研究；

2. 短链脂肪酸和膳食纤维对小鼠脑部能量代谢的影响研究；

3. 以能量代谢为靶点的癫痫发病机制及创新药物筛选研究；

4. 靶向线粒体的抗癫痫药物筛选及机制研究。

科研经历

1. 湖北省科学技术厅，湖北省技术创新专项（重大项目），220171403，类糖皮质激素药物在新型冠状病毒肺炎中的临床应用，2020-03至2022-06，30万元，结题，参与

2. 武汉大学，新冠基金专项，2042020kfxg22，类糖皮质激素药物在新型冠状病毒肺炎中的临床应用，2020-03至2020-05，6万元，结题，参与

3. 与宁波市第一医院合作开展“脂质组学揭示痤疮患者皮脂成分谱及与痤疮分级的相关性研究”，担任课题设计者和参与实施者。

4. 与浙江大学第一附属医院合作开展“脂质组学和16SrDNA测序揭示痤疮患者皮脂成分谱和菌群多态性研究”，担任课题设计者和参与实施者。

5. 与武汉市第三医院及武汉大学中南医院合作开展“仿生皮肤脂质护理膏联合液体敷料治疗痤疮的临床疗效观察”，担任课题设计者和参与实施者。

发表文章

[1] Cheng Y, Zeng X, Mai Q, Bai X, Jiang Y, Li J, Fan S, Ding H. Insulin injections inhibits PTZ-induced mitochondrial dysfunction, oxidative stress and neurological deficits via the SIRT1/PGC-1α/SIRT3 pathway[J]. Biochimica Et Biophysica Acta. Molecular Basis of Disease, 2021, 1867(6): 166124.

[2] Cheng Y, Zeng X, Wang H, Ding H. A case series evaluating the impact of a combination treatment for acne vulgaris containing linoleic acid, linolenic acid, and lecithin[J]. Dermatologic Therapy, 2020, 33(6): e14505.

[3] Cheng Y, Mai Q, Zeng X, Wang H, Xiao Y, Tang L, Li J, Zhang Y, Ding H. Propionate relieves pentylenetetrazol-induced seizures, consequent mitochondrial disruption, neuron necrosis and neurological deficits in mice[J]. Biochemical Pharmacology, 2019, 169: 113607.

[4] Cheng Y, Luo F, Zhang Q, Sang Y, Chen X, Zhang L, Liu Y, Li X, Li J, Ding H, Mei Y. α-Lipoic acid alleviates pentetrazol-induced neurological deficits and behavioral dysfunction in rats with seizures via an Nrf2 pathway[J]. RSC Advances, 2018, 8(8): 4084–4092.

[5] Wu Q, Dong J, Bai X, Jiang Y, Li J, Fan S, Cheng Y*, Jiang G. Propionate ameliorates diabetes-induced neurological dysfunction through regulating the PI3K/Akt/eNOS signaling pathway[J]. European Journal of Pharmacology, 2022, 925: 174974.

[6] Li D, Bai X, Jiang Y, Cheng Y*. Butyrate alleviates PTZ-induced mitochondrial dysfunction, oxidative stress and neuron apoptosis in mice via Keap1/Nrf2/HO-1 pathway[J]. Brain Research Bulletin, 2021, 168: 25–35.

[7] Ding H, Yin S, Cheng Y, Cai Y, Huang W, Deng W. Neurologic manifestations of nonhospitalized patients with COVID-19 in Wuhan, China[J]. MedComm, 2020, 1(2): 253–256.

[8] Tian H, Cheng Y, Zhang Y, Bai X, Jiang Y, Li J, Fan S, Ding H. 18β-Glycyrrhetinic acid alleviates demyelination by modulating the microglial M1/M2 phenotype in a mouse model of cuprizone-induced demyelination[J]. Neuroscience Letters, 2021, 755: 135871.

[9] Xiao Y, Li X, Zeng X, Wang H, Mai Q, Cheng Y, Li J, Tang L, Ding H. A Low ω-6/ω-3 Ratio High-Fat Diet Improves Rat Metabolism via Purine and Tryptophan Metabolism in the Intestinal Tract, While Reversed by Inulin[J]. Journal of Agricultural and Food Chemistry, 2019, 67(26): 7315–7324.

[10] Tang L, Li X-L, Deng Z-X, Xiao Y, Cheng Y-H, Li J, Ding H. Conjugated linoleic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice through dual inhibition of COX-2/5-LOX and TLR4/NF-κB signaling[J]. The Journal of Nutritional Biochemistry, 2020, 81: 108379.

[11] Li J, Zhang Y, Zeng X, Cheng Y, Tang L, Hong D, Yang X. Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1[J]. The Journal of Nutritional Biochemistry, 2022, 99: 108862.

[12] Chen X, Tan J, Zhang L, Liu Y, Cheng Y, Zhang Q, Ding H. Apigenin ameliorates vascular injury in rats with high fructose-induced metabolic disturbance by inhibiting PI3K/AKT/GLUT1[J]. RSC advances, 2018, 8(43): 24470–24476.